Other contributions of CaNIOS members:

Other Lupus research projects of CaNIOS members:

1. Prevalence of SARDs and Medication Use in SARDs using Administrative Data. (Dr. Christine Peschken and Dr. Carol Hitchon, work in progress).

2. SARDS in Manitoba First Nations People.  Prevalence, Outcomes, and Care Gaps. (Dr. Christine Peschken and Dr. Carol Hitchon, work in progress).

3. Impact of Lung Involvement on Quality of Life in Systemic Lupus Erythematosus. (Dr. Shicka Mittoo, summer project by resident Saif Al Mubaihsi)

4. Lung Disease Over Time in Systemic Lupus Erythematosus. (Dr. Shicka Mittoo, research summer student: Sangeetha Thiviyarajah).

5. Induction of a Murine Model of Anti-phospholipid Syndrome. (Dr. Joyce Rauch, in collaboration with Dr. Jerrold Levine, University of Illinois at Chicago; and Dr. Yahye Merhi and Dr. Eric Thorin, University of Montreal).

6. Apoptotic Cell Modulation of Macrophage Function in Health and Autoimmunity. (Dr. Joyce Rauch, in collaboration with Dr. Jerrold Levine, University of Illinois at Chicago).

7. The Role of Anti-phospholipid Antibodies and Innate Immune Activation in Thrombosis. (Dr. Joyce Rauch, with Dr. Patrick Laplante - Post-doctoral fellow).

8.The Role of Toll-like Receptor (TLR) Activation in a Murine Model of Systemic Lupus Erythematosus (SLE). (Dr. Joyce Rauch, with David Salem - M.Sc. candidate in Microbiology and Immunology).

9.Adherence to Guidelines in SLE and Agreement with SLE Guidelines and Gaps in Guidelines (Dr. Janet Pope).

10.Dissection of B Cell Receptor Signaling in Lupus Patients (Dr. Emil Nashi).

11.Dissection of T Cell Receptor Signaling in Lupus Patients (Dr. Emil Nashi).

12. Dissection of mTOR Signaling in Lupus Patients (Dr. Emil Nashi).

13. Lymphoma Risk in SLE (Drs. Sasha Bernatsky, Ann Clark, John Hanly, Christine Peschken, Susan Barr, Steven Edworthy, and Paul R. Fortin).

14. Long-term Outcome of Lupus Pregnancies (Drs. Sasha Bernatsky, Christian Pineau, Ann Clark, and Evelyn Vinet).

15. SLE Annual Assessment: Predicting Disease Outcomes in Patients with Lupus (Drs. Sasha Bernatsky, Christian Pineau, and Ann Clark).

16.  The Systemic Lupus International Collaborating Clinics (SLICC) Registry for Atherosclerosis in SLE (Drs. Sasha Bernatsky, Christian Pineau, Ann Clark, John Hanly, Christine Peschken and Paul R Fortin).

17. The Systemic Lupus International Collaborating Clinics (SLICC) Study of Involvement of the Nervous System in SLE (Drs. Sasha Bernatsky, Christian Pineau, Ann Clark, John Hanly, Christine Peschken and Paul R Fortin).

18.  Association between Anti-Ro and QTc Prolongation (Drs. Sasha Bernatsky, Christian Pineau, and Ann Clark).

19. Examining B Cell Receptor Signaling in Patients with Lupus.  (Dr. Emil Nashi)

20. How Genes Determine SLE Phenotype and Outcome (Dr. Earl Silverman).

21. Epidemiology of Systemic Autoimmune Rheumatic diseases including SLE (Dr. Antonio Avina-Zubieta).

22. Incidence, Prevalence, Direct Medical Costs, Comorbidities (cardiovascular disease, osteoporosis fractures, diabetes, cancer, end stage renal disease) and Mortality (Dr. Antonio Avina-Zubieta).

Journal Articles (Published)

2012

Allen D, Fischer A, Bshouty Z, Robinson D, Peschken C, Hitchon C, El-Gabalawy  H, Meyers M, Mittoo S. Evaluating Systemic Lupus Erythematosus Patients for Lung Involvement. Lupus. 2012 Jul 19. [Epub ahead of print] PubMed PMID: 22813546. 

Tomasson G, Boers M, Walsh M, Lavalley M, Cuthbertson D, Carette S, Davis JC, Hoffman GS, Khalidi NA, Langford CA, McAlear CA, McCune WJ, Monach PA, Seo P, Specks U, Spiera R, St Clair EW, Stone JH, Ytterberg SR, Merkel PA. Assessment of Health-related Quality of Life as an Outcome Measure in Granulomatosis with Polyangiitis (Wegener’s). Arthritis Care Res 2012; 64: 273-9. 

Urowitz M, Gladman D, Ibanez D, Fortin P, Bae A, Gordon C, Clarke AE, Bernatsky S, et al.  Evolution of Disease Burden Over 5 Years in a Multicentre Inception SLE Cohort. Arthritis Care & Research 2012:64: 132–137.

Vinet E, Pineau CA, Bernatsky S.  Infertility in Women with Systemic Lupus Erythematosus: Comment on the Article by Clowse et al. Arthritis Care Res (Hoboken). 2012 Jul 6. doi: 10.1002/acr.21790. [Epub ahead of print]. 

Vinet E, Labrecque J, Pineau C, Clarke A, St-Pierre Y, Platt R, Bernatsky S. A Population-Based Assessment of Live Births in Women with Systemic Lupus Erythematosus. Ann Rheum Dis. 2012 Apr;71(4):557-9.

Barnabe C, Joseph L, Belisle P, Labrecque J, Barr SG, Fritzler MJ, Svenson LW, Peschken CA, Hemmelgarn B, Bernatsky S. Prevalence of Autoimmune Inflammatory Myopathy in Alberta's First Nations Population. Arthritis Care Res (Hoboken). 2012 Jan;64(1):138-43. 

Barnabe C, Joseph L, Belisle P, Labrecque J, Edworthy S, Barr S, Fritzler M, Svenson L, Hemmelgarn B,Bernatsky S.  Increased Prevalence of Systemic Lupus Erythematosus and Systemic Sclerosis in Alberta’s First Nations Population. Arthritis Care & Research 2012 Jan;64(1):138-43.

Bernatsky S, Easton D, Dunning A, Michailidou K, Ramsey-Goldman R, Gordon P, Clarke A, Foulkes W. Decreased Breast Cancer Risk in SLE: The Search for a Genetic Basis Continues Lupus (Accepted February 24, 2012)

Bernatsky S, Kale M, Ramsey-Goldman R, Gordon C, Clarke AE. Systemic Lupus and Malignancies. Curr Opin Rheumatol. 2012 Mar;24(2):177-81.

2011

Appenzeller S, Pineau C, Clarke AE. Acute Lupus Myocarditis: Clinical Features and Outcome. Lupus2011;20:981– 8.

Bernatsky S, Clarke A. Breast, Ovarian, and Endometrial Malignancies in Systemic Lupus Erythematosus(SLE): A Pooled Analysis. British Journal of Cancer 2011;104: 1478-1481.

Bernatsky S, Linehan T, and Hanly JG. The Accuracy of Administrative Data Diagnoses of Systemic Autoim-mune Rheumatic Diseases. Journal of Rheumatology 2011 Aug;38(8):1612-6.

Bourre-Tessier J., Huynh T., Clarke AE., Bernatsky S, Pineau C. Features Associated with Cardiac Abnormalities in Systemic Lupus Erythematosus. Lupus 2011 Dec;20(14):1518-25.

Esmaeilbeigi F, Juvet S, Hwang D, Mittoo S.  Desguamative Interstitial Pneumonitis in a Patient with Systemic Lupus Erythematosis. Can Respir J.  2012 Jan-Feb; 19(1):50-2.

Flowers CH, Hennis AHM, Alarcon GS, Alpert D, Amigo MC, Avina-Zubieta JA,   et al . Report of an International Symposium on Narrowing the Gap in the Treatment and Study of SLE Worldwide: Minimum Best Practices in the Management and Monitoring of Moderate to Severe SLE and Improving Outcomes in Constrained Environments.  Cur Rev Musculoskelet Med 2011;4:105-112 (Open Access).

Grayson PC, Tomasson G, Cuthbertson D, Carette S, Hoffman GS, Khalidi NA, Langford, CA, McAlear CA, Monach PA, Seo P, Warrington KJ, Ytterberg SR, Merkel PA. Association of Vascular Physical Examination Findings and Arteriographic Lesions in Large Vessel Vasculitis. J Rheumatol 2012;39:303-9. 

Grayson,PC, Maksimowicz-McKinnon K, Clark TM, Tomasson G, Cuthbertson D, Carette S, Khalidi NA, Langford CA, Monach PA, Seo P, Warrington KJ, Ytterberg SR, Hoffman GS, Merkel PA: for the Vasculitis Clinical Research Consortium. Distribution of Arterial Lesions in Takayasu’s Arteritis and Giant Cell Arteritis. Ann Rheunm Dis 2012;71:1329-1334. 

Hanly JG, Urowitz MB, Jackson D, Bae SC, Gordon C, Wallace DJ, Clarke A, Bernatsky S, et al SLICC. SF-36 Summary & Subscale Scores are Reliable Outcomes of Neuropsychiatric Events in SLE.. Ann Rheum Dis. 2011;70:961-7.

Hanly JG, Urowitz  MB, Su L, Gordon C, Bae SC, Sanchez-Guerrero J, Romero-Diaz  J, Wallace DJ, Clarke AE, Ginzler EM, Merrill JT, Isenberg DA, Rahman A, Petri M, Fortin PR, Gladman DD, Bruce,IN, Steinsson, K, Dooley MA, Khamashta MA, Alarcón GS, Fessler BJ, Ramsey-Goldman R, Manzi S, Zoma  A, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen D L, Peschken CA, Inanc M, Theriault C, Thompson K and Farewell V.  Seizure Disorders in Systemic Lupus Erythematosus: Results from an International, Prospective, Inception Cohort Study.  Annals of Rheumatic Disease 2012 in press. 

Hanly JG, Urowitz MB, Su L, Bae S-C, Gordon C,  Sanchez-Guerrero J, Clarke A,  Bernatsky S, Vasudevan A, Isenberg D, Rahman A, Wallace DJ, Fortin PR, Gladman D, Dooley MA, Bruce I, Steinsson K, Khamashta M, Manzi S, Ramsey-Goldman R, Sturfelt G, Nived O, van Vollenhoven R, Ramos-Casals M, Aranow C, Mackay M, Kalunian K, Alarcón GS, Fessler BJ, Ruiz-Irastorza G, Petri M, Lim S, Kamen D, Peschken CA, Farewell V, Thompson K, Theriault C, Merrill JT. Autoantibodies as Biomarkers for the Prediction of Neuropsychiatric Events in Systemic Lupus Erythematosus Ann Rheum Dis. 2011 Oct;70(10):1726-32. 

Hemmati I, Blocka K.  Shrinking Lung Syndrome:  A Case Report and Review of the Literature.  Manuscript submitted.

Ippolito A, Wallace DJ, Gladman D, Fortin PR, Urowitz M, Werth V, Costner M, Gordon C, Alarcón GS, Ramsey-Goldman R, Maddison P, Clarke A, Bernatsky S et al. Autoantibodies in SLE Lupus. 2011;20:250-5.

Kelley JM, Monach PA, JI C, Zhou Y, Wu J, Tanaka S, Mahr AD, Johnson S, McAlear C, Cuthbertson D, Carette S, Davis JC Jr, Dellaripa PF, Hoffman GS, Khalidi N, Langford CA, Seo P, St Clair EW, Specks U, Stone JH, Spiera RF, Ytterberg SR, Merkel PA, Edberg JC, Kimberly RP. IgA and IgG Antineutrophil Cytoplasmic Antibody Engagement of Fc Receptor Genetic Variants Influences Granulomatosis withPolyangiitis. Proc Natl Acad Sci U S A 2011; 108: 20736-41.

Lim LS, Benseler SM, Tyrrell PN, Harvey E, Herbert D, Charron M, et al. Predicting Longitudinal Trajectory of Bone Mineral Density in Pediatric Systemic Lupus Erythematosus patients. Annals of the rheumatic diseases. 2012. Epub 2012/03/24.

Monach PA, Kumpers P, Lukasz A, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Carette S, Ding L, Hoffman GS, Iklé D, Kallenberg CG, Khalidi NA, Langford CA, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Haubitz M, Merkel PA. Circulating Angiopoietin-2 as a Biomarker in ANCA-Associated Vasculitis. PLoS One 2012;7:e30197. 

Pagnoux C, Thorne C, Mandelcorn ED, Carette S. CNS Involvement in Acute Posterior Multifocal Placoid Pigment Epitheliopathy. Can J neurol Sci 2011; 38: 526-8. Senior Responsible Author

Vinet E, Clarke AE, Gordon C, Urowitz MB, Hanly JG, Pineau CA, Bernatsky S. Decreased Live Birthsin Women with Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). 2011 Jul;63(7):1068-72. doi: 10.1002/acr.20466.

Bernatsky S, Ramsey-Goldman R, Gordon C, Clarke A. Short Report: Prostate Cancer in SLE. International Journal of Cancer 2011;129: 2966–2969.

Bernatsky S, Panopalis P, Pineau C, Hudson M, St. Pierre Y, and Clarke A. Health Care Costs of Inflammatory Myopathies. J Rheumatol. 2011 May;38(5):885-8.

Bernatsky S, Lix L, Hanly JG, Hudson M, Badley E, Peschken C, et al.  Surveillance of Systemic Autoimmune Rheumatic Diseases Using Administrative Data. Rheumatol Int. 2011;31(4):549-54.     

Bernatsky S, Fournier M, Pineau CA, Clarke AE, Vinet E, Smargiassi A. Associations between Ambient Fine Particulate Levels and Disease Activity in Systemic Lupus Erythematosus (SLE). Environ Health Perspect. 2011;119(1):45-9.

Petri M, Orbai AM, Alarcón, GS, Gordon C, Merrill JT, Fortin PR, Bruce I, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sanchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth V, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta M, Jacobsen S, Buyon J, Maddison P, Dooley MA, van Vollenhoven RF, GinzleE, Stoll T, Peschken CA, Jorizzo JL, Callen JP, Lim S, Fessler B, Inanc M, Kamen D, Rahman A, Steinsson K, Franks Jr. AG, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman M, McGwin Jr. G, Magder LS.  Derivation and Validation of Systemic Lupus International Collaborating Clinics (SLICC)Classification Criteria for Systemic Lupus Erythematosus. Arthritis and Rheumatism 2011.  Manuscript ID: AR-11-1144.

2006

Bernatsky S, Ramsey-Goldman R, Clarke AE. Revisiting the issue of malignancy risk in systemic lupus erythematosus. Curr Rheumatol Rep. 2005 Dec;7(6):476-81. Review. Erratum in: Curr Rheumatol Rep. 2006 Apr;8(2):iii. PMID: 16303109. 

2005

Bernatsky S, Clarke A, Abrahamowicz M, Neville C, Karp I, Pineau CA. A comparison of prospective and retrospective evaluations of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for systemic lupus erythematosus. J Rheumatol. 2005 May;32(5):820-3. PMID: 15868615 

2004 

Bernatsky S, Clarke A, Ramsey-Goldman R, Boivin JF, Joseph L, Rajan R, Manzi S. Breast cancer stage at time of detection in women with systemic lupus erythematosus. Lupus. 2004;13(6):469-72. PMID: 15303575. 

Bernatsky S, Ramsey-Goldman R, Gordon C, Joseph L, Boivin JF, Rajan R, Allen A, Moore AD, Leung MH, Clarke A. Factors associated with abnormal Pap results in systemic lupus erythematosus. Rheumatology (Oxford). 2004 Nov;43(11):1386-9. Epub 2004 Jul 27. PMID: 15280571 

Bernatsky S, Clarke A, Ramsey-Goldman R, Joseph L, Boivin JF, Rajan R, Moore AD, Leung MH, Allen A, Gordon C. Hormonal exposures and breast cancer in a sample of women with systemic lupus erythematosus. Rheumatology (Oxford). 2004 Sep;43(9):1178-81. Epub 2004 Jun 29. PMID: 15226516 

2003

Bernatsky S, Ramsey-Goldman R, Boivin JF, Joseph L, Moore AD, Rajan R, Clarke A. Do traditional Gail model risk factors account for increased breast cancer in women with lupus? J Rheumatol. 2003 Jul;30(7):1505-7. PMID: 12858448

2002 

Bernatsky S, Boivin JF, Joseph L, St Pierre Y, Moore A, Rajan R, Clarke A. Prevalence of factors influencing cancer risk in women with lupus: social habits, reproductive issues, and obesity. J Rheumatol. 2002 Dec;29(12):2551-4. PMID: 12465150. 

Bernatsky S. Discussion on inflammatory bowel disease is not associated with an increased risk of lymphoma. Gastroenterology. 2002 Aug;123(2):653. PMID: 12145829. 

Bernatsky S, Clarke A, Ramsey-Goldman R. Malignancy and systemic lupus erythematosus. Curr Rheumatol Rep. 2002 Aug;4(4):351-8. Review. PMID: 12126588. 

Isenberg D, Ramsey-Goldman R, Clarke A, Bernatsky S; SLICC Group. Systemic Lupus International Collaborating Clinics. Lupus and malignancy. Lupus. 2002; 11 (3):199. PMID: 11999888 

Manuscripts In Press 

Bernatsky S, Lix, L, Hanly J, Fortin PR, Badley E, Peschken C, Pineau C, Hudson M, Clarke A, Smith M, Bélisle P, Lagace C, Joseph L. Surveillance of Systemic Autoimmune Rheumatic Diseases Using Administrative Data. Rheumatol Int. (In Press – PMID: 20665025)(July 28, 2010).

Touma Z., Gladman DD, Tulloch-Reid D., Toloza S., Ibanez D., Fortin PR, Urowitz MB. Burden of Autoantibodies and Association with Disease Activity and Damabe in Systemic Lupus Erythematosus. Clinical and Experimental Rheumatology (In Press – CER 73509. July, 2010) 

Abstracts (Published) 

Chan K, Dekis A, Clarke E, Pineau C, Vinet E, Nashi E, Bernatsky S. Hospitalizations in Patients with Systemic Lupus Erythematosus: Updated analyses from 2006-2011. Abstract, 2012 Lupus Update Conference.

Dekis A, Pineau CA, Vinet E, Nashi E, Bernatsky S, Clarke AE. Hospitalization Rates and Reasons for Admission in a Clinical SLE Cohort. Abstract, 2012 Laurentians rheumatology conference.

Faludi M, Mao A, Vinet E, Clarke A, Pineau C, Bernatsky S, Nashi E. B Cell Receptor Signalling Studies in Patients with Lupus: Preliminary Results. Abstract, 2012 Lupus Update Conference.

Lao W, Neville C, Pineau C, Clarke A, Da Costa D, Nashi E, Neville A, Mill C, Singer W, Bernatsky S. Yoga in Systemic Lupus Erythematosus: Preliminary Results of a Pragmatic Trial. Abstract, 2012 Canadian Arthritis Network meeting.

Morogan A, Nashi E, Pineau C, Clarke A, Vinet E.  Am I or Am I Not a Disease Manifestation?: A Case of“MI” in Churg-Strauss Syndrome. Abstract, 2011 Laurentians rheumatology conference.

Nashi, E, Vinet E, Pineau C. Polyarteritis Nodosa Presenting as a Prolonged Course of Refractory Angioedema. Submitted, Journal of Rheumatology.

Bernatsky S, Ramsey-Goldman R, Gordon C, Manzi S, Nived O, Bae SC, Ruiz-Irastorza G, Costenbader KH, Jacobsen S, Isenberg D, Rahman A, Witte T, Sturfelt GK, Lee JL, Turnbull E , Clarke AE, Non-Hodgkin's Lymphoma in Systemic Lupus 9th International Congress on Systemic Lupus Erythematosus, Vancouver, BC, Canada. June, 2010 

Tulloch-Reid D.M., Gladman D.D., Fortin PR, Herzenberg A., Cole E, Urowitz MB. The ISN/RPS Classification of Renal Biopsy as a Determinant of Prognosis in a Prospective Lupus Cohort. Arthritis and Rheumatism. 2009;60(9suppl):16341. 

Bernatsky S, Ramsey-Goldman R, Oen K, Rosenberg, Gordon C, Manzi S et al. Malignancy in Pediatric-Onset SLE. Arthritis and Rheumatism 2009;60(S10): S280. 

Bernatsky S, Ramsey-Goldman R, Urowitz M, Gladman D, Ruiz-Irastorza G, Bae S et al. Effects of SLE Activity On Lymphoma Risk: Preliminary Results of a Case-Cohort Study. Arthritis and Rheumatism 2009;60(S10). 

Bernatsky S, Ramsey-Goldman R, Gordon C, Manzi S, Nived O, Bae S et al. Histology, Prognostic Factors, Treatment, & Outcome in SLE Patients with Non-Hodgkin's Lymphoma (NHL) ACR/ARHP Annual Scientific Meeting. Philadelphia, PA, USA. Oct. 2009. 

Urowitz M, Gladman DD, Fortin PR, Sanchez-Guerrero J, Clarke AE, Bae SC, Gordon C, Isenberg D, Hanly J, Merrill J, Ginzler E, Alarcon G, Wallace D, Petri M, Steinsson K, Dooley MA, Manzi S, Bruce I Maddison P, Sturfelt G, Nived O, Zoma A, Aranow C, Ramsey-Goldman R, van Vollenhoven R, Khamashta M. Systemic lupus international collaborating clinics (SLICC) inception cohort registry to study risk factors for atherosclerosis (SLICC RAS): First follow-up report. Arthritis & Rheumatism 2005;52 (9 suppl) S 608.

Bernatsky S, Ramsey-Goldman R, Boivin J-F, Joseph L, Rajan R, Zoma A, Manzi S, Ginzler E, Urowitz M, Gladman D, Fortin PR, Petri M, Edworthy S, Gordon C, Bae S-C, Sibley J, Isenberg D, Aranow C, Dooley M-A, Steinsson K, Nived O, Sturfelt G, Alarcon G, Clarke AE. An international cohort study of cancer in systemic lupus erythematosus (SLE). Arthritis and Rheumatism 2004;50 (9 suppl)S592 

Bernatsky S, Clarke A, Boivin JF, Joseph L, Rajan R, Manzi S, Urowitz M, Gladman D, Fortin P, Gordon C, Bae SC, Sibley J, Edworthy S, Barr S, Isenberg D, Rahman A, El- Gabalawy H, McCarthy T, Hanly J, Pope J, Sturfelt G, Nived O, St.Pierre Y, Ramsey- Goldman R. Racial Factors Relating to Cancer Occurrence in Systemic Lupus (SLE). Arthritis and Rheumatism 2003;48(9 suppl):S696. 

Bernatsky S, Clarke A, Boivin JF, Joseph L, Rajan R, St. Pierre Y. Malignancy in SLE: A Meta-Analysis (poster and oral presentation at NIH-sponsored meeting “SLE: Targets for New Therapeutics,” Bethesda, 2002) 

Bernatsky S, Clarke A, Boivin JF, St. Pierre Y, Joseph L, Rajan R. The prevalence of risk factors for malignancy in women with SLE. (SLE: Targets for New Therapeutics, Bethesda, 2002. 

Bernatsky S, Boivin J-F, Clarke A, Rajan R. Cancer risk in systemic lupus erythematosus: a meta-analysis. Arthritis & Rheumatism 2001;44[9 suppl]:S244. 

Bernatsky S, Clarke A, St. Pierre Y, Boivin J-F, Joseph L, Rajan R. The prevalence of factors influencing cancer risk in lupus: social habits, reproductive issues and obesity. Arthritis & Rheumatism 2001;44[9 suppl]:S244.